研究開発

研究論文

科学・医学の研究結果を扱う「PlosOne」(2013年2月22日)に、新規細胞治療イメージング用磁性粒子に関する論文が掲載されるなど、細胞加工技術や細胞移植などを中心とした研究成果がある。

  1. 「In vivo imaging of transplanted islets labeled with a novel cationic nanoparticle.」(Oishi K, Miyamoto Y, Saito H, Murase K, Ono K, Sawada M, Watanabe M, Noguchi Y, Fujiwara T, Hayashi S, Noguchi H.)PLoS One. 2013;8(2):e57046 H25年2月
  2. 「Preclinical biodistribution and safety study of reduced expression in immortalized cells/Dickkopf-3-encoding adenoviral vector for prostate cancer gene therapy. 」(Sugimoto M, Watanabe M, Haku H, Li SA, Noguchi H, Ueki H, Sakaguchi M, Huh NH, Nasu Y, Kumon H.)Oncol. Rep. 28(5), 1645-1652. H24年8月
  3. 「A novel gene expression system for detecting viable bladder cancer cells.」(Ueki H, Wakanabe M, Haku H, Huang P, Li SA, Ochiai K, Hirata T, Noguchi H, Yamada H, Takei K, Nasu Y, Kashiwakura Y, Kumon H.Int. J.)Oncol. 41(1), 135-140. H24年3月
  4. 「Monitoring transplanted adipose tissue-derived stem cells combined with heparin in the liver by fluorescence imaging using quantum dots.」(Yukawa H, Watanabe M, Kaji N, Okamoto Y, Tokeshi M, Miyamoto Y, Noguchi H, Baba Y, Hayashi S.)Biomaterials 33(7), 2177-2186 H24年 3月
  5. 「Cryopreservation of human adipose tissue-derived stem/progenitor cells using the silk protein sericin.」(Miyamoto Y, Oishi K, Yukawa H, Noguchi H, Sasaki M, Iwata H, Hayashi S.)Cell Transplant. 21(2-3), 617-622 H24年2月
  6. 「Transplantation of osteogenically differentiated mouse iPS cells for bone repair.」(Hayashi T, Misawa H, Nakahara H, Noguchi H, Yoshida A, Kobayashi N, Tanaka M, Ozaki T.)Cell Transplant. 21(2-3), 591-600 H24年2月
  7. 「Improved pancreatic islet isolation outcome in autologous transplantation for chronic pancreatitis.」(Naziruddin B, Matsumoto S, Noguchi H, Takita M, Shimoda M, Fujita Y, Chujo D, Tate C, Onaca N, Lamont J, Kobayashi N, Levy MF.)Cell Transplant. 21(2-3), 553-558 H24年2月
  8. 「Adverse events in clinical islet transplantation: one institutional experience.」(Takita M, Matsumoto S, Noguchi H, Shimoda M, Ikemoto T, Chujo D, Tamura Y, Olsen GS, Naziruddin B, Purcell K, Onaca N, Levy MF.)Cell Transplant. 21(2-3), 547-551 H24年2月
  9. 「Fresh islets are more effective for islet transplantation than cultured islets.」(Noguchi H, Naziruddin B, Jackson A, Shimoda M, Ikemoto T, Fujita Y, Chujo D, Takita M, Peng H, Sugimoto K, Itoh T, Kobayashi N, Onaca N, Levy MF, Matsumoto S.)Cell Tranaplant. 21(2-3), 517-523 H24年2月
  10. 「Comparison of ulinastatin, gabexate mesilate, and nafamostat mesilate in preservation solution for islet isolation.(Noguchi H, Naziruddin B, Jackson A, Shimoda M, Fujita Y, Chujo D, Takita M, Peng H, Sugimoto K, Itoh T, Kobayashi N, Ueda M, Okitsu T, Iwanaga Y, Nagata H, Liu X, Kamiya H, Onaca N, Levy MF, Matsumoto S.)Cell Transplant. 21(2-3), 509-516 H24年2月
  11. 「Islet purification method using large bottles effectively achieves high islet yield from pig pancreas.」(Shimoda M, Noguchi H, Fujita Y, Takita M, Ikemoto T, Chujo D, Naziruddin B, Levy MF, Kobayashi N, Grayburn PA, Matsumoto S.)Cell Transplant. 21(2-3), 501-508 H24年2月
  12. 「Evaluation of osmolality of density gradient for human islet purification.」(Noguchi H, Naziruddin B, Shimoda M, Fujita Y, Chujo D, Takita M, Peng H, Sugimoto K, Itoh T, Kobayashi N, Onaca N, Levy MF, Matsumoto S.)Cell Transplant. 21(2-3), 493-500 H24年2月
  13. 「Improvement of porcine islet isolation by inhibition of trypsin activity during pancreas preservation and digestion using α1-antitrypsin.」(Shimoda M, Noguchi H, Fujita Y, Takita M, Ikemoto T, Chujo D, Naziruddin B, Levy MF, Kobayashi N, Grayburn PA, Matsumoto S.)Cell Transplant. 21(2-3), 465-471 H24年2月
  14. 「Secretory unit of islet transplant objects (SUITO) index can predict severity of hypoglycemic episodes in clinical islet cell transplantation.」(Takita M, Matsumoto S, Qin H, Noguchi H, Shimoda M, Chujo D, Itoh T, Sugimoto K, Onaca N, Naziruddin B, Levy MF.)Cell Transplant. 21(1), 91-98 H24年1月
  15. 「Estimation of the distribution of intravenously injected adipose tissue-derived stem cells labeled with quantum dots in mice organ through the determination of their metallic components by ICPMS.」(Takasaki Y, Watanabe M, Yukawa H, Sabarudin A, Inagaki K, Kaji N, Okamoto Y, Tokeshi M, Miyamoto Y, Noguchi H, Umemura T, Hayashi S, Baba Y, Haraguchi H.)Anal. Chem. 83(21), 8252-8258 H23年11月
  16. 「Pancreas procurement and preservation for islet transplantation: personal considerations.」(Noguchi H.)J. Transplant. 2011, 783168 H23年9月
  17. Tumor suppressor REIC/Dkk-3 interacts with the dynein light chain, Tctex-1.」(Ochiai K, Watanabe M, Ueki H, Huang P, Fujii Y, Nasu Y, Noguchi H, Hirata T, Sakaguchi M, Huh NH, Kashiwakura Y, Kaku H, Kumon H.)Biochem. Biophys. Res. Commun. 412(2), 391-395 H23年8月
  18. 「Cluster analysis of self-monitoring blood glucose assessments in clinical islet cell transplantation for type 1 diabetes.」(Takita M, Matsumoto S, Noguchi H, Shimoda M, Chujo D, Itoh T, Sugimoto K, Sorelle JA, Onaca N, Naziruddin B, Levy MF.)Diabetes Care 34(8), 1799-1803 H23年8月
  19. 「Embryonic body formation using the tapered soft stencil for cluster culture device.」(Yukawa H, Noguchi H, Hayashi S.)Biomaterials 32(15), 3729-3738 H23年5月
  20. Yukawa H., Kagami Y., Watanabe M., Oishi K., Miyamoto Y., Okamoto Y., Tokeshi M., Kaji N., Noguchi H., Ono K., Sawada M., Baba Y., Hamajima N., Hayashi S. (2010) Quantum dots labeling using octa-arginine peptides for imaging of adipose tissue-derived stem cells. Biomaterials 31(14), 4094-4103.
  21. Yukawa H., Ikeuchi S., Noguchi H., Miyamoto Y.,Ikuta k., Hayashi S. Embryonic Body Formation Using The Tapered Soft Stencil For Cluster Culture Device. Biomaterials, 32, 3729-3738.
  22. Yukawa H., Noguchi H., Oishi K., Takagi S., Miyamoto Y., Hayashi S. (2009) Cell Transplantation of Adipose Tissue-Derived Stem Cells in Combination with Heparin Attenuated Acute Liver Failure in Mice. Cell Transplant. 18(5-6), 611-618.